Engineering highly efficient backsplicing and translation of synthetic circRNAs
Circular RNAs (circRNAs) are highly stable RNA molecules that are attractive INTENSIVE EYE CREAM templates for expression of therapeutic proteins and non-coding RNAs.In eukaryotes, circRNAs are primarily generated by the spliceosome through backsplicing.Here, we interrogate different molecular elements including intron type and length, Alu repeats,